Seroatlas · Human Serome Atlas

OR5AS1

Olfactory receptor 5AS1

Also known as: O5AS1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N127
Gene: OR5AS1
Ensembl: ENSG00000181785
Chromosome: 11
Canonical length: 324 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8N127|OR5AS1
     1  MLESNYTMPT EFLFVGFTDY LPLRVTLFLV FLLVYTLTMV GNILLIILVN INSSLQIPMY
    61  YFLSNLSFLD ISCSTAITPK MLANFLASRK SISPYGCALQ MFFFASFADA ECLILAAMAY
   121  DRYAAICNPL LYTTLMSRRV CVCFIVLAYF SGSTTSLVHV CLTFRLSFCG SNIVNHFFCD
   181  IPPLLALSCT DTQINQLLLF ALCSFIQTST FVVIFISYFC ILITVLSIKS SGGRSKTFST
   241  CASHLIAVTL FYGALLFMYL QPTTSYSLDT DKVVAVFYTV VFPMFNPIIY SFRNKDVKNA
   301  LKKLLERIGY SNEWYLNRLR IVNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

retina: 2.6 nTPM
bone marrow: 1.6 nTPM
skin: 1.2 nTPM
liver: 1.1 nTPM
testis: 0.9 nTPM
epididymis: 0.7 nTPM

Single-cell type

epididymal basal cells: 0.2 nCPM
distal convoluted tubule cells: 0.1 nCPM
goblet cells: 0.1 nCPM
late primary spermatocytes: 0.1 nCPM
loop of henle epithelial cells: 0.1 nCPM
prostatic glandular cells: 0.1 nCPM

Immune cell

basophil: 1.5 nTPM
neutrophil: 0.9 nTPM
naive B-cell: 0.6 nTPM
classical monocyte: 0.4 nTPM
non-classical monocyte: 0.4 nTPM
gdT-cell: 0.3 nTPM

Brain region

cerebellum: 49 nTPM
cerebral cortex: 48 nTPM
white matter: 48 nTPM
basal ganglia: 39 nTPM
amygdala: 39 nTPM
hippocampal formation: 38 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: -1.18
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5AS1 as an antibody target. Whether an autoantibody or antibody against OR5AS1 could matter depends on whether native OR5AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5AS1 is annotated at the cell surface, where native OR5AS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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