Seroatlas · Human Serome Atlas

OR5A2

Olfactory receptor 5A2

Also known as: OR5A2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGI9
Gene: OR5A2
Ensembl: ENSG00000172324
Chromosome: 11
Canonical length: 324 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8NGI9|OR5A2
     1  MAVGRNNTIV TKFILLGLSD HPQMKIFLFM LFLGLYLLTL AWNLSLIALI KMDSHLHMPM
    61  YFFLSNLSFL DICYVSSTAP KMLSDIITEQ KTISFVGCAT QYFVFCGMGL TECFLLAAMA
   121  YDRYAAICNP LLYTVLISHT LCLKMVVGAY VGGFLSSFIE TYSVYQHDFC GPYMINHFFC
   181  DLPPVLALSC SDTFTSEVVT FIVSVVVGIV SVLVVLISYG YIVAAVVKIS SATGRTKAFS
   241  TCASHLTAVT LFYGSGFFMY MRPSSSYSLN RDKVVSIFYA LVIPVVNPII YSFRNKEIKN
   301  AMRKAMERDP GISHGGPFIF MTLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

retina: 1 nTPM
bone marrow: 0.7 nTPM
choroid plexus: 0.5 nTPM
skin: 0.5 nTPM
epididymis: 0.4 nTPM
skeletal muscle: 0.4 nTPM

Single-cell type

late spermatids: 1.2 nCPM
early spermatids: 0.6 nCPM
late primary spermatocytes: 0.5 nCPM
müller glia: 0.2 nCPM
differentiating spermatogonia: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
eosinophil: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 11 nTPM
hypothalamus: 10 nTPM
cerebral cortex: 9.9 nTPM
white matter: 9.9 nTPM
thalamus: 9.3 nTPM
amygdala: 9.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.02
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5A2 as an antibody target. Whether an autoantibody or antibody against OR5A2 could matter depends on whether native OR5A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5A2 is annotated at the cell surface, where native OR5A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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