Seroatlas · Human Serome Atlas

OR5A1

Olfactory receptor 5A1

Also known as: OR5A1_HUMAN, OR5A1P, OST181

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGJ0
Gene: OR5A1
Ensembl: ENSG00000172320
Chromosome: 11
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NGJ0|OR5A1
     1  MSITKAWNSS SVTMFILLGF TDHPELQALL FVTFLGIYLT TLAWNLALIF LIRGDTHLHT
    61  PMYFFLSNLS FIDICYSSAV APNMLTDFFW EQKTISFVGC AAQFFFFVGM GLSECLLLTA
   121  MAYDRYAAIS SPLLYPTIMT QGLCTRMVVG AYVGGFLSSL IQASSIFRLH FCGPNIINHF
   181  FCDLPPVLAL SCSDTFLSQV VNFLVVVTVG GTSFLQLLIS YGYIVSAVLK IPSAEGRWKA
   241  CNTCASHLMV VTLLFGTALF VYLRPSSSYL LGRDKVVSVF YSLVIPMLNP LIYSLRNKEI
   301  KDALWKVLER KKVFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR5A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.4 nTPM
retina: 0.4 nTPM
skin: 0.3 nTPM
testis: 0.2 nTPM
adrenal gland: 0.1 nTPM
appendix: 0.1 nTPM

Single-cell type

early spermatids: 1.9 nCPM
late spermatids: 1 nCPM
undifferentiated spermatogonia: 1 nCPM
foveolar cells: 0.6 nCPM
lymphatic endothelial cells: 0.5 nCPM
late primary spermatocytes: 0.4 nCPM

Immune cell

neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 8.7 nTPM
cerebral cortex: 8.7 nTPM
white matter: 8.3 nTPM
basal ganglia: 7.6 nTPM
thalamus: 7.3 nTPM
midbrain: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.63
gnomAD pLI: 0
gnomAD missense Z: -0.8
DepMap mean gene effect: -0.2
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR5A1 as an antibody target. Whether an autoantibody or antibody against OR5A1 could matter depends on whether native OR5A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR5A1 is annotated at the cell surface, where native OR5A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR5A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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