Seroatlas · Human Serome Atlas

OR4Q3

Olfactory receptor 4Q3

Also known as: OR4Q3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH05
Gene: OR4Q3
Canonical length: 313 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR4Q3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NH05|OR4Q3
     1  MKKEQDSNVT EFVLLGLSSS WELQLFLFLL FLFFYIAIVL GNLLIVVTVQ AHAHLLQSPM
    61  YYFLGHLSFI DLCLSCVTVP KMLGDFLQQG KSISFSGCLA QIYFLHFLGA SEMFLLTVMA
   121  YDRYVAICNP LRYLTVMNPQ LCLWLVLACW CGGFIHSIMQ VILVIQLPFC GPNELDNFYC
   181  DVPQVIKLAC MDTYVVEVLV IANSGLLSLV CFLVLLFSYA IILITLRTHF CQGQNKVFST
   241  CASHLTVVSL IFVPCVFIYL RPFCSFSVDK IFSLFYTVIT PMLNPLIYTL RNTDMKTAMK
   301  KLRIKPCGIP LPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4Q3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.7 nTPM
cerebral cortex: 0.5 nTPM
basal ganglia: 0.4 nTPM
medulla oblongata: 0.4 nTPM
pons: 0.4 nTPM
amygdala: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -3.1

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4Q3 as an antibody target. Whether an autoantibody or antibody against OR4Q3 could matter depends on whether native OR4Q3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4Q3 is annotated at the cell surface, where native OR4Q3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4Q3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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