Seroatlas · Human Serome Atlas

OR4N4C

Olfactory receptor 4N4C

Also known as: ORN4C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A096LPK9
Gene
OR4N4C
Ensembl
ENSG00000279408
Chromosome
15
Canonical length
316 aa
Protein class
Predicted membrane proteins
Subcellular location
Centrosome

OverviewNCBI Gene

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>A0A096LPK9|OR4N4C
     1  MKIANNTVVT EFILLGLTQS QDIQLLVFVL ILIFYLIILP GNFLIIFTIR SDPGLTAPLY
    61  LFLGNLAFLD ASYSFIVAPR MLVDFLSEKK VISYRGCITQ LFFLHFLGGG EGLLLVVMAF
   121  DRYIAICRPL HCSTVMNPRA CYAMMLALWL GGFVHSIIQV VLILRLPFCG PNQLDNFFCD
   181  VRQVIKLACT DMFVVELLMV FNSGLMTLLC FLGLLASYAV ILCHVRRAAS EGKNKAMSTC
   241  TTRVIIILLM FGPAIFIYIC PFRALPADKM VSLFHTVIFP LMNPMIYTLR NQEVKTSMKR
   301  LLSRHVVCQV DFIIRN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4N4C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
2.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 0.3 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4N4C as an antibody target. Whether an autoantibody or antibody against OR4N4C could matter depends on whether native OR4N4C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4N4C is annotated at the cell surface, where native OR4N4C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4N4C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR4N4C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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