Seroatlas · Human Serome Atlas

OR4N2

Olfactory receptor 4N2

Also known as: OR4N2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGD1
Gene: OR4N2
Ensembl: ENSG00000176294
Chromosome: 14
Canonical length: 307 aa
Protein class: G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q8NGD1|OR4N2
     1  MESENRTVIR EFILLGLTQS QDIQLLVFVL VLIFYFIILP GNFLIIFTIK SDPGLTAPLY
    61  FFLGNLAFLD ASYSFIVAPR MLVDFLSAKK IISYRGCITQ LFFLHFLGGG EGLLLVVMAF
   121  DRYIAICRPL HYPTVMNPRT CYAMMLALWL GGFVHSIIQV VLILRLPFCG PNQLDNFFCD
   181  VPQVIKLACT DTFVVELLMV FNSGLMTLLC FLGLLASYAV ILCRIRGSSS EAKNKAMSTC
   241  ITHIIVIFFM FGPGIFIYTR PFRAFPADKV VSLFHTVIFP LLNPVIYTLR NQEVKASMKK
   301  VFNKHIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4N2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 3.5 nTPM

Expression across tissuesHPA

Tissue

testis: 3.5 nTPM
cerebral cortex: 0.5 nTPM
tongue: 0.5 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

early spermatids: 68 nCPM
late primary spermatocytes: 64 nCPM
late spermatids: 7.1 nCPM
mucous neck cells: 3.1 nCPM
early primary spermatocytes: 2.9 nCPM
mesothelial cells: 2.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.7 nTPM
pons: 0.7 nTPM
white matter: 0.6 nTPM
cerebellum: 0.4 nTPM
cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -2.19
DepMap mean gene effect: -0.4
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4N2 as an antibody target. Whether an autoantibody or antibody against OR4N2 could matter depends on whether native OR4N2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4N2 is annotated at the cell surface, where native OR4N2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4N2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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