Seroatlas · Human Serome Atlas

OR4M2B

Olfactory receptor 4M2

Also known as: ORM2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0X1KG70
Gene
OR4M2B
Ensembl
ENSG00000182974
Chromosome
15
Canonical length
313 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>A0A0X1KG70|OR4M2B
     1  METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS LDPHLTSPMY
    61  FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDECIAQ LFFLHFAGAS EMFLLTVMAF
   121  DLYTAICRPL HYATIMNQRL CCILVALSWR GGFIHSIIQV ALIVRLPFCG PNELDSYFCD
   181  ITQVVRIACA NTFPEELVMI CSSGLISVVC LIALLMSYAF LLALLKKLSG SGENTNRAVS
   241  TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLHNPIIYT LRNKEVKAAM
   301  RKLVTKYILC KEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4M2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.5 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM
  • basal ganglia: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 0.3 nTPM
  • pons: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • thalamus: 0.1 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4M2B as an antibody target. Whether an autoantibody or antibody against OR4M2B could matter depends on whether native OR4M2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4M2B is annotated at the cell surface, where native OR4M2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4M2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR4M2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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