Seroatlas · Human Serome Atlas

OR4M2

Olfactory receptor 4M2

Also known as: OR4M2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGB6
Gene: OR4M2
Ensembl: ENSG00000274102
Chromosome: 15
Canonical length: 313 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGB6|OR4M2
     1  METANYTKVT EFVLTGLSQT PEVQLVLFVI FLSFYLFILP GNILIICTIS LDPHLTSPMY
    61  FLLANLAFLD IWYSSITAPE MLIDFFVERK IISFDGCIAQ LFFLHFAGAS EMFLLTVMAF
   121  DLYTAICRPL HYATIMNQRL CCILVALSWR GGFIHSIIQV ALIVRLPFCG PNELDSYFCD
   181  ITQVVRIACA NTFPEELVMI CSSGLISVVC LIALLMSYAF LLALFKKLSG SGENTNRAMS
   241  TCYSHITIVV LMFGPSIYIY ARPFDSFSLD KVVSVFNTLI FPLRNPIIYT LRNKEVKAAM
   301  RKLVTKYILC KEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4M2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

testis: 0.4 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 20 nCPM
late spermatids: 10 nCPM
late primary spermatocytes: 5.6 nCPM
astrocytes: 0.1 nCPM
early primary spermatocytes: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.96
gnomAD pLI: 0
gnomAD missense Z: -2.21

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4M2 as an antibody target. Whether an autoantibody or antibody against OR4M2 could matter depends on whether native OR4M2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4M2 is annotated at the cell surface, where native OR4M2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4M2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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