Seroatlas · Human Serome Atlas

OR4K17

Olfactory receptor 4K17

Also known as: OR4KH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGC6
Gene: OR4K17
Ensembl: ENSG00000176230
Chromosome: 14
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NGC6|OR4K17
     1  MKLLNQSQVS EFILLGLTSS QDVEFLLFAL FSVIYVVTVL GNLLIIVTVF NTPNLNTPMY
    61  FLLGNLSFVD MTLASFATPK VILNLLKKQK VISFAGCFTQ IFLLHLLGGV EMVLLVSMAF
   121  DRYVAICKPL HYMTIMNKKV CVLLVVTSWL LGLLHSGFQI PFAVNLPFCG PNVVDSIFCD
   181  LPLVTKLACI DIYFVQVVIV ANSGIISLSC FIILLISYSL ILITIKNHSP TGQSKARSTL
   241  TAHITVVILF FGPCIFIYIW PFGNHSVDKF LAVFYTIITP ILNPIIYTLR NKEMKISMKK
   301  LWRAFVNSRE DT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4K17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 5.3 nTPM

Expression across tissuesHPA

Tissue

liver: 5.3 nTPM
bone marrow: 1.8 nTPM
retina: 1.2 nTPM
skeletal muscle: 0.7 nTPM
duodenum: 0.5 nTPM
skin: 0.5 nTPM

Single-cell type

late primary spermatocytes: 0.5 nCPM
bergmann glia: 0.1 nCPM
early spermatids: 0.1 nCPM
hofbauer cells: 0.1 nCPM
microglia: 0.1 nCPM
müller glia: 0.1 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.3 nTPM
eosinophil: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebellum: 12 nTPM
white matter: 12 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 9.3 nTPM
basal ganglia: 8.8 nTPM
amygdala: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.82
gnomAD pLI: 0
gnomAD missense Z: -1.97
DepMap mean gene effect: 0.02
DepMap dependency class: none

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4K17 as an antibody target. Whether an autoantibody or antibody against OR4K17 could matter depends on whether native OR4K17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4K17 is annotated at the cell surface, where native OR4K17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4K17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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