Seroatlas · Human Serome Atlas

OR4K14

Olfactory receptor 4K14

Also known as: OR4KE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGD5
Gene: OR4K14
Ensembl: ENSG00000169484
Chromosome: 14
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q8NGD5|OR4K14
     1  MDPQNYSLVS EFVLHGLCTS RHLQNFFFIF FFGVYVAIML GNLLILVTVI SDPCLHSSPM
    61  YFLLGNLAFL DMWLASFATP KMIRDFLSDQ KLISFGGCMA QIFFLHFTGG AEMVLLVSMA
   121  YDRYVAICKP LHYMTLMSWQ TCIRLVLASW VVGFVHSISQ VAFTVNLPYC GPNEVDSFFC
   181  DLPLVIKLAC MDTYVLGIIM ISDSGLLSLS CFLLLLISYT VILLAIRQRA AGSTSKALST
   241  CSAHIMVVTL FFGPCIFVYV RPFSRFSVDK LLSVFYTIFT PLLNPIIYTL RNEEMKAAMK
   301  KLQNRRVTFQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4K14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4K14 as an antibody target. Whether an autoantibody or antibody against OR4K14 could matter depends on whether native OR4K14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4K14 is annotated at the cell surface, where native OR4K14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4K14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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