Seroatlas · Human Serome Atlas

OR4F3

Olfactory receptor 4F3/4F16/4F29

Also known as: OR4F16, OR4F29, OR4F3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IEY1
Gene: OR4F3
Ensembl: ENSG00000230178
Chromosome: 5
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q6IEY1|OR4F3
     1  MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNILIVFSVT TDPHLHSPMY
    61  FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVVGGV EMVLLIAMAF
   121  DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD
   181  LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL
   241  SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
   301  VCKQLVIYKR IS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4F3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

testis: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 3 nTPM
cerebral cortex: 2.5 nTPM
pons: 2.5 nTPM
white matter: 2.4 nTPM
amygdala: 2.3 nTPM
basal ganglia: 2.3 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4F3 as an antibody target. Whether an autoantibody or antibody against OR4F3 could matter depends on whether native OR4F3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4F3 is annotated at the cell surface, where native OR4F3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4F3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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