Seroatlas · Human Serome Atlas

OR4F15

Olfactory receptor 4F15

Also known as: O4F15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGB8
Gene: OR4F15
Ensembl: ENSG00000182854
Chromosome: 15
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NGB8|OR4F15
     1  MNGMNHSVVS EFVFMGLTNS REIQLLLFVF SLLFYFASMM GNLVIVFTVT MDAHLHSPMY
    61  FLLANLSIID MAFCSITAPK MICDIFKKHK AISFRGCITQ IFFSHALGGT EMVLLIAMAF
   121  DRYMAICKPL HYLTIMSPRM CLYFLATSSI IGLIHSLVQL VFVVDLPFCG PNIFDSFYCD
   181  LPRLLRLACT NTQELEFMVT VNSGLISVGS FVLLVISYIF ILFTVWKHSS GGLAKALSTL
   241  SAHVTVVILF FGPLMFFYTW PSPTSHLDKY LAIFDAFITP FLNPVIYTFR NKDMKVAMRR
   301  LCSRLAHFTK IL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4F15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

appendix: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

proximal tubule cells: 1.5 nCPM
schwann cells: 1.4 nCPM
endometrial secretory cells: 0.3 nCPM
podocytes: 0.3 nCPM
papillary tip epithelial cells: 0.2 nCPM
early spermatids: 0.1 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 1.9 nTPM
cerebral cortex: 1.7 nTPM
white matter: 1.7 nTPM
hippocampal formation: 1.5 nTPM
pons: 1.5 nTPM
amygdala: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0.09
gnomAD missense Z: -1.06
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4F15 as an antibody target. Whether an autoantibody or antibody against OR4F15 could matter depends on whether native OR4F15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4F15 is annotated at the cell surface, where native OR4F15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4F15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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