Seroatlas · Human Serome Atlas

OR4E2

Olfactory receptor 4E2

Also known as: OR4E2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGC2
Gene: OR4E2
Canonical length: 313 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR4E2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

313 residues, UniProt reviewed canonical sequence.

>Q8NGC2|OR4E2
     1  MDSLNQTRVT EFVFLGLTDN RVLEMLFFMA FSAIYMLTLS GNILIIIATV FTPSLHTPMY
    61  FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCITQ LFFLHLFACA EIFLLIIVAY
   121  DRYVAICTPL HYPNVMNMRV CIQLVFALWL GGTVHSLGQT FLTIRLPYCG PNIIDSYFCD
   181  VPLVIKLACT DTYLTGILIV TNSGTISLSC FLAVVTSYMV ILVSLRKHSA EGRQKALSTC
   241  SAHFMVVALF FGPCIFIYTR PDTSFSIDKV VSVFYTVVTP LLNPFIYTLR NEEVKSAMKQ
   301  LRQRQVFFTK SYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

early spermatids: 3.3 nCPM
cholangiocytes: 2 nCPM
late primary spermatocytes: 0.3 nCPM
podocytes: 0.3 nCPM
b-cells: 0.2 nCPM
breast secretory cells: 0.2 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.8 nTPM
cerebral cortex: 0.7 nTPM
basal ganglia: 0.6 nTPM
hippocampal formation: 0.6 nTPM
amygdala: 0.5 nTPM
pons: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0.01
gnomAD missense Z: -0.73
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4E2 as an antibody target. Whether an autoantibody or antibody against OR4E2 could matter depends on whether native OR4E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4E2 is annotated at the cell surface, where native OR4E2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...