Seroatlas · Human Serome Atlas

OR4E1

Olfactory receptor 4E1

Also known as: OR4E1_HUMAN, OR4E1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C645
Gene: OR4E1
Ensembl: ENSG00000276240
Chromosome: 14
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>P0C645|OR4E1
     1  MEEAILLNQT SLVTYFRLRG LSVNHKARIA MFSMFLIFYV LTLIGNVLIV ITIIYDHRLH
    61  TPMYFFLSNL SFIDVCHSTV TVPKMLRDVW SEEKLISFDA CVTQMFFLHL FACTEIFLLT
   121  VMAYDRYVAI CKPLQYMIVM NWKVCVLLAV ALWTGGTIHS IALTSLTIKL PYCGPDEIDN
   181  FFCDVPQVIK LACIDTHVIE ILIVSNSGLI SVVCFVVLVV SYAVILVSLR QQISKGKRKA
   241  LSTCAAHLTV VTLFLGHCIF IYSRPSTSLP EDKVVSVFFT AVTPLLNPII YTLRNEEMKS
   301  ALNKLVGRKE RKEEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4E1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

appendix: 0.1 nTPM
bone marrow: 0.1 nTPM
lymph node: 0.1 nTPM
spleen: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late primary spermatocytes: 0.7 nCPM
early spermatids: 0.4 nCPM
basal prostatic cells: 0.3 nCPM
colonocytes: 0.1 nCPM
enterocytes: 0.1 nCPM
prostatic club cells: 0.1 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 0.6 nTPM
choroid plexus: 0.6 nTPM
cerebral cortex: 0.5 nTPM
hippocampal formation: 0.5 nTPM
thalamus: 0.5 nTPM
white matter: 0.5 nTPM

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4E1 as an antibody target. Whether an autoantibody or antibody against OR4E1 could matter depends on whether native OR4E1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4E1 is annotated at the cell surface, where native OR4E1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4E1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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