Seroatlas · Human Serome Atlas

OR4D1

Olfactory receptor 4D1

Also known as: OR4D1_HUMAN, OR4D3, TPCR16

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15615
Gene: OR4D1
Ensembl: ENSG00000141194
Chromosome: 17
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q15615|OR4D1
     1  MEPQNTTQVS MFVLLGFSQT QELQKFLFLL FLLVYVTTIV GNLLIMVTVT FDCRLHTPMY
    61  FLLRNLALID LCYSTVTSPK MLVDFLHETK TISYQGCMAQ IFFFHLLGGG TVFFLSVMAY
   121  DRYIAISQPL RYVTIMNTQL CVGLVVAAWV GGFVHSIVQL ALILPLPFCG PNILDNFYCD
   181  VPQVLRLACT DTSLLEFLMI SNSGLLVIIW FLLLLISYTV ILVMLRSHSG KARRKAASTC
   241  TTHIIVVSMI FIPCIYIYTW PFTPFLMDKA VSISYTVMTP MLNPMIYTLR NQDMKAAMRR
   301  LGKCLVICRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.5 nTPM
lymph node: 0.4 nTPM
spleen: 0.2 nTPM
testis: 0.2 nTPM
tonsil: 0.2 nTPM
appendix: 0.1 nTPM

Single-cell type

megakaryocytes: 6.2 nCPM
megakaryocyte progenitors: 5 nCPM
megakaryocyte-erythroid progenitors: 4.3 nCPM
retinal ganglion cells: 3.9 nCPM
innate lymphoid cells: 3.6 nCPM
early spermatids: 2.8 nCPM

Immune cell

NK-cell: 1.9 nTPM
naive CD8 T-cell: 1.4 nTPM
naive CD4 T-cell: 1.2 nTPM
gdT-cell: 0.9 nTPM
MAIT T-cell: 0.9 nTPM
basophil: 0.8 nTPM

Brain region

cerebellum: 2.4 nTPM
white matter: 2.4 nTPM
pons: 2.2 nTPM
choroid plexus: 2.1 nTPM
midbrain: 2.1 nTPM
cerebral cortex: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4D1 as an antibody target. Whether an autoantibody or antibody against OR4D1 could matter depends on whether native OR4D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4D1 is annotated at the cell surface, where native OR4D1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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