OR4C5
Olfactory receptor 4C5
Also known as: OR4C5_HUMAN, OR4C5P, OR4C5Q
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NGB2
- Gene
- OR4C5
- Ensembl
- ENSG00000176540
- Chromosome
- 11
- Canonical length
- 326 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
Canonical amino-acid sequenceUniProt
326 residues, UniProt reviewed canonical sequence.
>Q8NGB2|OR4C5
1 MYVSNCNPCA IHRKINYPNT KLDFEQVNNI TEFILLGLTQ NAEAQKLLFA VFTLIYFLTM
61 VDNLIIVVTI TTSPALDSPV YFFLSFFSFI DGCSSSTMAP KMIFDLLTEK KTISFSGCMT
121 QLFVEHFFGG VEIILLVVMA YDCYVAICKP LYYLITMNRQ VCGLLVAMAW VGGFLHALIQ
181 MLLIVWLPFC GPNVIDHFIC DLFPLLKLSC TDTHVFGLFV AANSGLMCML IFSILITSYV
241 LILCSQRKAL STCAFHITVV VLFFVPCILV YLRPMITFPI DKAVSVFYTV VTPMLNPLIY
301 TLRNTEVKNA MKQLWSQIIW GNNLCDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR4C5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- cardiomyocytes: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.66
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.91
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR4C5 as an antibody target. Whether an autoantibody or antibody against OR4C5 could matter depends on whether native OR4C5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR4C5 is annotated at the cell surface, where native OR4C5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR4C5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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