Seroatlas · Human Serome Atlas

OR4C45

Olfactory receptor 4C45

Also known as: O4C45_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NMZ5
Gene
OR4C45
Canonical length
306 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR4C45 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>A6NMZ5|OR4C45
     1  MNNVTEFILL GLTHNPELQK FLFVMFLITY LITLAGNLLI SVIIFISPAL GSPMYLFLSY
    61  LSIIDIFYSS SIAPKMIFDL ISENNTISFN GCMTQLFTEH FFAAAETILL SVMAYDCYVA
   121  ICKPLHYATI MTQSMCGFLM VVAGILGFVH GGIQTLFIAQ LPFCGPNVID HFMCDLVPLL
   181  ELACTDTHTL GPLIAANSGS LCFLIFSILD ASYVIILCSL RSHSSEGHLK ALSSCASHIF
   241  TVILFFVPCS YLYLRPLTSF PTDKAVTVFC TLFTPMLNPL IYTVKNKAVK NVIKKLWKQI
   301  MTTDDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR4C45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
0 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • appendix: 0 nTPM
  • bone marrow: 0 nTPM
  • breast: 0 nTPM
  • cerebral cortex: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR4C45 as an antibody target. Whether an autoantibody or antibody against OR4C45 could matter depends on whether native OR4C45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR4C45 is annotated at the cell surface, where native OR4C45 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR4C45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OR4C45. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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