Seroatlas · Human Serome Atlas

OR3A3

Olfactory receptor 3A3

Also known as: OR3A3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47888
Gene: OR3A3
Canonical length: 321 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR3A3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>P47888|OR3A3
     1  MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV
    61  EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD
   121  CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASWAC AFTNALTHTV AMSTLNFCGP
   181  NEVNHFYCDL PQLFQLSCSS TQLNELLLFV AAAFMAVAPL VFISVSYAHV VAAVLQIRSA
   241  EGRKKAFSTC GSHLTVVGIF YGTGVFSYMR LGSVESSDKD KGVGVFMTVI NPMLNPLIYS
   301  LRNTDVQGAL CQLLVGKRSL T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR3A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.3 nTPM
testis: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
lymph node: 0.1 nTPM

Single-cell type

cardiomyocytes: 4.9 nCPM
pdcs: 3.1 nCPM
medullary thymic epithelial cells: 2.4 nCPM
epicardial cells: 2.3 nCPM
retinal horizontal cells: 2 nCPM
myonuclei: 1.5 nCPM

Immune cell

plasmacytoid DC: 8 nTPM
basophil: 0.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

white matter: 2.7 nTPM
cerebellum: 2 nTPM
cerebral cortex: 2 nTPM
thalamus: 1.9 nTPM
basal ganglia: 1.7 nTPM
amygdala: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.57

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR3A3 as an antibody target. Whether an autoantibody or antibody against OR3A3 could matter depends on whether native OR3A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR3A3 is annotated at the cell surface, where native OR3A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR3A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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