Seroatlas · Human Serome Atlas

OR3A2

Olfactory receptor 3A2

Also known as: OR3A2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47893
Gene: OR3A2
Canonical length: 321 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR3A2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

321 residues, UniProt reviewed canonical sequence.

>P47893|OR3A2
     1  MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG NLSILAAVLV
    61  EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST ISYDACLSQL FFFHLLAGMD
   121  CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ RMLVAASLAC AFTNALTHTV AMSTLNFCGP
   181  NEVNHFYCDL PQLFQLSCSS TQLNELLLFA VGFIMAGTPL VLIITAYSHV AAAVLRIRSV
   241  EGRKKAFSTC GSHLTVVCLF FGRGIFNYMR LGSEEASDKD KGVGVFNTVI NPMLNPLIYS
   301  LRNPDVQGAL WQIFLGRRSL T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR3A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 2.7 nTPM

Expression across tissuesHPA

Tissue

testis: 2.7 nTPM
retina: 0.8 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM
epididymis: 0.3 nTPM
lymph node: 0.3 nTPM

Single-cell type

early primary spermatocytes: 64 nCPM
microglia: 52 nCPM
undifferentiated spermatogonia: 45 nCPM
sertoli cells: 42 nCPM
pituicytes/fscs: 41 nCPM
differentiating spermatogonia: 30 nCPM

Immune cell

basophil: 1 nTPM
memory B-cell: 0.8 nTPM
plasmacytoid DC: 0.8 nTPM
MAIT T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM
memory CD4 T-cell: 0.4 nTPM

Brain region

white matter: 6.8 nTPM
thalamus: 6.1 nTPM
basal ganglia: 4 nTPM
cerebral cortex: 3.8 nTPM
midbrain: 3.7 nTPM
amygdala: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.53

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR3A2 as an antibody target. Whether an autoantibody or antibody against OR3A2 could matter depends on whether native OR3A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR3A2 is annotated at the cell surface, where native OR3A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR3A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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