Seroatlas · Human Serome Atlas

OR3A1

Olfactory receptor 3A1

Also known as: OLFRA03, OR17-40, OR3A1_HUMAN, OR40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P47881
Gene: OR3A1
Ensembl: ENSG00000180090
Chromosome: 17
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>P47881|OR3A1
     1  MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA AVLVEPKLHT
    61  PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC LTQLFFFHLF VGVDCFLLTA
   121  MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA SWACAFTNAL THTVAMSTLN FCGPNVINHF
   181  YCDLPQLFQL SCSSTQLNEL LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA
   241  FSTCGSHLTV VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV
   301  QSAIWRMLTG RRSLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR3A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
cervix: 0.1 nTPM
choroid plexus: 0.1 nTPM
epididymis: 0.1 nTPM
placenta: 0.1 nTPM
retina: 0.1 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

naive CD8 T-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM
memory B-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

white matter: 2 nTPM
thalamus: 1.5 nTPM
hypothalamus: 1.2 nTPM
amygdala: 0.9 nTPM
basal ganglia: 0.8 nTPM
medulla oblongata: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0.02
gnomAD missense Z: -0.98
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR3A1 as an antibody target. Whether an autoantibody or antibody against OR3A1 could matter depends on whether native OR3A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR3A1 is annotated at the cell surface, where native OR3A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR3A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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