Seroatlas · Human Serome Atlas

OR2W3

Olfactory receptor 2W3

Also known as: OR2W3_HUMAN, OR2W3P, OR2W8P, OST718

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3T1
Gene: OR2W3
Ensembl: ENSG00000238243
Chromosome: 1
Canonical length: 314 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

314 residues, UniProt reviewed canonical sequence.

>Q7Z3T1|OR2W3
     1  MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR LDPHLHTPMY
    61  FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ LFLFLGLGGV ECLLLAVMAY
   121  DRCVAICKPL HYMVIMNPRL CRGLVSVTWG CGVANSLAMS PVTLRLPRCG HHEVDHFLRE
   181  MPALIRMACV STVAIEGTVF VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT
   241  CGSHLTVVSL FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA
   301  LGRLLLGKRE LGKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2W3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 12 nTPM
thyroid gland: 5.9 nTPM
hypothalamus: 2.3 nTPM
cerebral cortex: 1.7 nTPM
basal ganglia: 1.4 nTPM
midbrain: 1.3 nTPM

Single-cell type

erythrocytes: 0.4 nCPM
late spermatids: 0.3 nCPM
early spermatids: 0.1 nCPM
erythrocyte progenitors: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

myeloid DC: 0.2 nTPM
total PBMC: 0.2 nTPM
eosinophil: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM

Brain region

hypothalamus: 14 nTPM
pons: 10 nTPM
midbrain: 8.7 nTPM
medulla oblongata: 6.7 nTPM
cerebral cortex: 4.9 nTPM
thalamus: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: -0.66
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2W3 as an antibody target. Whether an autoantibody or antibody against OR2W3 could matter depends on whether native OR2W3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2W3 is annotated at the cell surface, where native OR2W3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2W3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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