Seroatlas · Human Serome Atlas

OR2V2

Olfactory receptor 2V2

Also known as: OR2V2_HUMAN, OR2V3, OST713

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96R30
Gene: OR2V2
Ensembl: ENSG00000182613
Chromosome: 5
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q96R30|OR2V2
     1  METWVNQSYT DGFFLLGIFS HSTADLVLFS VVMAVFTVAL CGNVLLIFLI YMDPHLHTPM
    61  YFFLSQLSLM DLMLVCTNVP KMAANFLSGR KSISFVGCGI QIGLFVCLVG SEGLLLGLMA
   121  YDRYVAISHP LHYPILMNQR VCLQITGSSW AFGIIDGLIQ MVVVMNFPYC GLRKVNHFFC
   181  EMLSLLKLAC VDTSLFEKVI FACCVFMLLF PFSIIVASYA HILGTVLQMH SAQAWKKALA
   241  TCSSHLTAVT LFYGAAMFIY LRPRHYRAPS HDKVASIFYT VLTPMLNPLI YSLRNREVMG
   301  ALRKGLDRCR IGSQH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2V2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.3 nTPM
fallopian tube: 0.2 nTPM
appendix: 0.1 nTPM
pancreas: 0.1 nTPM
retina: 0.1 nTPM
skin: 0.1 nTPM

Single-cell type

medullary thymic epithelial cells: 2.4 nCPM
breast myoepithelial cells: 0.9 nCPM
fallopian tube ciliated cells: 0.5 nCPM
müller glia: 0.5 nCPM
b-cells: 0.3 nCPM
breast lactating cells: 0.2 nCPM

Immune cell

basophil: 0.7 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
naive B-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

white matter: 3.9 nTPM
thalamus: 3.1 nTPM
basal ganglia: 2.9 nTPM
cerebral cortex: 2.9 nTPM
choroid plexus: 2.9 nTPM
medulla oblongata: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0.08
gnomAD missense Z: -0.16
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2V2 as an antibody target. Whether an autoantibody or antibody against OR2V2 could matter depends on whether native OR2V2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2V2 is annotated at the cell surface, where native OR2V2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2V2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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