Seroatlas · Human Serome Atlas

OR2T8

Olfactory receptor 2T8

Also known as: OR2T8_HUMAN, OR2T8P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NH00
Gene: OR2T8
Ensembl: ENSG00000177462
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>A6NH00|OR2T8
     1  MENGSYTSYF ILLGLFNHTR AHQVLFMMVL SIVLTSLFGN SLMILLIHWD HRLHTPMYFL
    61  LSQLSLMDVM LVSTTVPKMA ADYLTGSKAI SRAGCGAQIF FLPTLGGGEC FLLAAMAYDR
   121  YAAVCHPLRY PTLMSWQLCL RMNLSCWLLG AADGLLQAVA TLSFPYCGAH EIDHFFCETP
   181  VLVRLACADT SVFENAMYIC CVLMLLVPFS LILSSYGLIL AAVLHMRSTE ARKKAFATCS
   241  SHVAVVGLFY GAAIFTYMRP KSHRSTNHDK VVSAFYTMFT PLLNPLIYSV KNSEVKGALT
   301  RCMGRCVALS RE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 1 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 1 nTPM
bone marrow: 0.6 nTPM
hypothalamus: 0.4 nTPM
basal ganglia: 0.3 nTPM
midbrain: 0.3 nTPM
testis: 0.3 nTPM

Single-cell type

megakaryocytes: 12 nCPM
retinal ganglion cells: 3.9 nCPM
megakaryocyte-erythroid progenitors: 2.8 nCPM
megakaryocyte progenitors: 2.7 nCPM
differentiating spermatogonia: 2.6 nCPM
thymocytes: 2.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1 nTPM
cerebral cortex: 0.9 nTPM
midbrain: 0.9 nTPM
pons: 0.9 nTPM
medulla oblongata: 0.6 nTPM
basal ganglia: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.47
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T8 as an antibody target. Whether an autoantibody or antibody against OR2T8 could matter depends on whether native OR2T8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T8 is annotated at the cell surface, where native OR2T8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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