Seroatlas · Human Serome Atlas

OR2T7

Olfactory receptor 2T7

Also known as: OR2T7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7T2
Gene: OR2T7
Canonical length: 308 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for OR2T7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

308 residues, UniProt reviewed canonical sequence.

>P0C7T2|OR2T7
     1  MPTLSFWVCS ATPVSPGFFA LILLVFVTSI ASNVVKIILI HIDSRLHTPM YFLLSQLSLR
    61  DILYISTIVP KMLVDQVMSQ RAISFAGCTA QHFLYLTLAG AEFFLLGLMS CDRYVAICNP
   121  LHYPDLMSRK ICWLIVAAAW LGGSIDGFLL TPVTMQFPFC ASREINHFFC EVPALLKLSC
   181  TDTSAYETAM YVCCIMMLLI PFSVISGSYT RILITVYRMS EAEGRRKAVA TCSSHMVVVS
   241  LFYGAAMYTY VLPHSYHTPE QDKAVSAFYT ILTPMLNPLI YSLRNKDVTG ALQKVVGRCV
   301  SSGKVTTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

epididymis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM
bone marrow: 0 nTPM
breast: 0 nTPM

Single-cell type

brain excitatory neurons: 0.2 nCPM
brain inhibitory neurons: 0.1 nCPM
oligodendrocyte progenitor cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 3.2 nTPM
white matter: 3 nTPM
amygdala: 2.9 nTPM
hippocampal formation: 2.8 nTPM
hypothalamus: 2.7 nTPM
basal ganglia: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -2.81

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T7 as an antibody target. Whether an autoantibody or antibody against OR2T7 could matter depends on whether native OR2T7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T7 is annotated at the cell surface, where native OR2T7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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