Seroatlas · Human Serome Atlas

OR2T4

Olfactory receptor 2T4

Also known as: OR2T4_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH00
Gene: OR2T4
Canonical length: 348 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR2T4 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q8NH00|OR2T4
     1  MDNITWMASH TGWSDFILMG LFRQSKHPMA NITWMANHTG WSDFILLGLF RQSKHPALLC
    61  VVIFVVFLMA LSGNAVLILL IHCDAHLHTP MYFFISQLSL MDMAYISVTV PKMLLDQVMG
   121  VNKISAPECG MQMFFYVTLA GSEFFLLATM AYDRYVAICH PLRYPVLMNH RVCLFLSSGC
   181  WFLGSVDGFT FTPITMTFPF RGSREIHHFF CEVPAVLNLS CSDTSLYEIF MYLCCVLMLL
   241  IPVVIISSSY LLILLTIHGM NSAEGRKKAF ATCSSHLTVV ILFYGAAIYT YMLPSSYHTP
   301  EKDMMVSVFY TILTPVVNPL IYSLRNKDVM GALKKMLTVE PAFQKAME

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM
midbrain: 0.4 nTPM
medulla oblongata: 0.3 nTPM
thalamus: 0.3 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0.19
gnomAD missense Z: -0.88
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T4 as an antibody target. Whether an autoantibody or antibody against OR2T4 could matter depends on whether native OR2T4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T4 is annotated at the cell surface, where native OR2T4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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