OR2T35
Olfactory receptor 2T35
Also known as: O2T35_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NGX2
- Gene
- OR2T35
- Ensembl
- ENSG00000177151
- Chromosome
- 1
- Canonical length
- 323 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
323 residues, UniProt reviewed canonical sequence.
>Q8NGX2|OR2T35
1 MGMEGLLQNS TNFVLTGLIT HPAFPGLLFA VVFSIFVVAI TANLVMILLI HMDSRLHTPM
61 YFLLSQLSIM DTIYICITVP KMLQDLLSKD KTISFLGCAV QIFYLTLIGG EFFLLGLMAY
121 DRYVAVCNPL RYPLLMNRRV CLFMVVGSWV GGSLDGFMLT PVTMSFPFCR SREINHFFCE
181 IPAVLKLSCT DTSLYETLMY ACCVLMLLIP LSVISVSYTH ILLTVHRMNS AEGRRKAFAT
241 CSSHIMVVSV FYGAAFYTNV LPHSYHTPEK DKVVSAFYTI LTPMLNPLIY SLRNKDVAAA
301 LRKVLGRCGS SQSIRVATVI RKGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR2T35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- oocytes: 4.6 nCPM
- proximal tubule cells: 2.1 nCPM
- epididymal efferent duct absorptive cells: 0.3 nCPM
- loop of henle epithelial cells: 0.2 nCPM
- distal convoluted tubule cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.59
- gnomAD pLI
- 0.19
- gnomAD missense Z
- -0.46
- DepMap mean gene effect
- -0.2
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR2T35 as an antibody target. Whether an autoantibody or antibody against OR2T35 could matter depends on whether native OR2T35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR2T35 is annotated at the cell surface, where native OR2T35 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR2T35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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