Seroatlas · Human Serome Atlas

OR2T3

Olfactory receptor 2T3

Also known as: OR2T3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH03
Gene: OR2T3
Ensembl: ENSG00000196539
Chromosome: 1
Canonical length: 318 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>Q8NH03|OR2T3
     1  MCSGNQTSQN QTASTDFTLT GLFAESKHAA LLYTVTFLLF LMALTGNALL ILLIHSEPRL
    61  HTPMYFFISQ LALMDLMYLC VTVPKMLVGQ VTGDDTISPS GCGIQMFFYL TLAGAEVFLL
   121  AAMAYDRYAA VCRPLHYPLL MNQRVCQLLV SACWVLGMVD GLLLTPITMS FPFCQSRKIL
   181  SFFCETPALL KLSCSDVSLY KTLMYLCCIL MLLAPIMVIS SSYTLILHLI HRMNSAAGHR
   241  KALATCSSHM IIVLLLFGAS FYTYMLPSSY HTAEQDMMVS AFYTIFTPVL NPLIYSLRNK
   301  DVTRALRSMM QSRMNQEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

proximal tubule cells: 0.2 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.77

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T3 as an antibody target. Whether an autoantibody or antibody against OR2T3 could matter depends on whether native OR2T3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T3 is annotated at the cell surface, where native OR2T3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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