Seroatlas · Human Serome Atlas

OR2T29

Olfactory receptor 2T29

Also known as: O2T29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH02
Gene: OR2T29
Ensembl: ENSG00000182783
Chromosome: 1
Canonical length: 315 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NH02|OR2T29
     1  MANITRMANH TGRLDFILMG LFRQSKHPAL LSVVIFVVFL KALSGNAVLI LLIHCDAHLH
    61  SPMYFFISQL SLMDMAYISV TVPKMLLDQV MGVNKVSAPE CGMQMFLYLT LAGSEFFLLA
   121  TMAYDRYVAI CHPLRYPVLM NHRVCLFLAS GCWFLGSVDG FMLTPITMSF PFCRSWEIHH
   181  FFCEVPAVTI LSCSDTSLYE TLMYLCCVLM LLIPVTIISS SYLLILLTVH RMNSAEGRKK
   241  AFATCSSHLT VVILFYGAAV YTYMLPSSYH TPEKDMMVSV FYTILTPVLN PLIYSLRNKD
   301  VMGALKKMLT VRFVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

kidney: 0.3 nTPM
prostate: 0.2 nTPM
salivary gland: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

proximal tubule cells: 3 nCPM
renal connecting tubule cells: 0.4 nCPM
distal convoluted tubule cells: 0.1 nCPM
loop of henle epithelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

memory B-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.1 nTPM
hippocampal formation: 0.1 nTPM
thalamus: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0.1
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T29 as an antibody target. Whether an autoantibody or antibody against OR2T29 could matter depends on whether native OR2T29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T29 is annotated at the cell surface, where native OR2T29 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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