Seroatlas · Human Serome Atlas

OR2T10

Olfactory receptor 2T10

Also known as: O2T10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGZ9
Gene: OR2T10
Ensembl: ENSG00000184022
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NGZ9|OR2T10
     1  MRLANQTLGG DFFLLGIFSQ ISHPGRLCLL IFSIFLMAVS WNITLILLIH IDSSLHTPMY
    61  FFINQLSLID LTYISVTVPK MLVNQLAKDK TISVLGCGTQ MYFYLQLGGA ECCLLAAMAY
   121  DRYVAICHPL RYSVLMSHRV CLLLASGCWF VGSVDGFMLT PIAMSFPFCR SHEIQHFFCE
   181  VPAVLKLSCS DTSLYKIFMY LCCVIMLLIP VTVISVSYYY IILTIHKMNS VEGRKKAFTT
   241  CSSHITVVSL FYGAAIYNYM LPSSYQTPEK DMMSSFFYTI LTPVLNPIIY SFRNKDVTRA
   301  LKKMLSVQKP PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

kidney: 4.6 nTPM
pancreas: 0.2 nTPM
prostate: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

proximal tubule cells: 26 nCPM
epididymal efferent duct absorptive cells: 2.8 nCPM
b-cells: 1.3 nCPM
loop of henle epithelial cells: 1.1 nCPM
podocytes: 1 nCPM
brain excitatory neurons: 0.7 nCPM

Immune cell

naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 0.7 nTPM
white matter: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
choroid plexus: 0.3 nTPM
hippocampal formation: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.3
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T10 as an antibody target. Whether an autoantibody or antibody against OR2T10 could matter depends on whether native OR2T10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T10 is annotated at the cell surface, where native OR2T10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...