Seroatlas · Human Serome Atlas

OR2T1

Olfactory receptor 2T1

Also known as: OR2T1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43869
Gene: OR2T1
Canonical length: 369 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR2T1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>O43869|OR2T1
     1  MWQEYYFLNV FFPLLKVCCL TINSHVVILL PWECYHLIWK ILPYIGTTVG SMEEYNTSST
    61  DFTFMGLFNR KETSGLIFAI ISIIFFTALM ANGVMIFLIQ TDLRLHTPMY FLLSHLSLID
   121  MMYISTIVPK MLVNYLLDQR TISFVGCTAQ HFLYLTLVGA EFFLLGLMAY DRYVAICNPL
   181  RYPVLMSRRV CWMIIAGSWF GGSLDGFLLT PITMSFPFCN SREINHFFCE APAVLKLACA
   241  DTALYETVMY VCCVLMLLIP FSVVLASYAR ILTTVQCMSS VEGRKKAFAT CSSHMTVVSL
   301  FYGAAMYTYM LPHSYHKPAQ DKVLSVFYTI LTPMLNPLIY SLRNKDVTGA LKRALGRFKG
   361  PQRVSGGVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2T1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
other brain neurons: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.2 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -0.71

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2T1 as an antibody target. Whether an autoantibody or antibody against OR2T1 could matter depends on whether native OR2T1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2T1 is annotated at the cell surface, where native OR2T1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2T1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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