Seroatlas · Human Serome Atlas

OR2L5

Olfactory receptor 2L5

Also known as: OR2L11, OR2L5_HUMAN, OR2L5P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG80
Gene: OR2L5
Ensembl: ENSG00000197454
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NG80|OR2L5
     1  MENYNQTSTD FILLGLFPPS KIGLFLFILF VLIFLMALIG NLSMILLIFL DTHLHTPMYF
    61  LLSQLSLIDL NYISTIVPKM ASDFLYGNKS ISFIGCGIQS FFFMTFAGAE ALLLTSMAYD
   121  RYVAICFPLH YPIRMSKRMY VLMITGSWMI GSINSCAHTV YAFRIPYCKS RAINHFFCDV
   181  PAMLTLACTD TWVYEYTVFL SSTIFLVFPF TGIACSYGWV LLAVYRMHSA EGRKKAYSTC
   241  STHLTVVTFY YAPFAYTYLC PRSLRSLTED KVLAVFYTIL TPMLNPIIYS LRNKEVMGAL
   301  TRVIQNIFSV KM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2L5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
retina: 0.2 nTPM
skeletal muscle: 0.1 nTPM
skin: 0.1 nTPM
spleen: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

oligodendrocytes: 13 nCPM
brain inhibitory neurons: 8.9 nCPM
brain excitatory neurons: 8.7 nCPM
hematopoietic stem cells: 8.7 nCPM
other brain neurons: 8.7 nCPM
oligodendrocyte progenitor cells: 6.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 7.3 nTPM
cerebral cortex: 7 nTPM
hypothalamus: 6.7 nTPM
pons: 5.7 nTPM
basal ganglia: 5.4 nTPM
cerebellum: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.03
DepMap mean gene effect: -0.2
DepMap dependency class: selective

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2L5 as an antibody target. Whether an autoantibody or antibody against OR2L5 could matter depends on whether native OR2L5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2L5 is annotated at the cell surface, where native OR2L5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2L5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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