Seroatlas · Human Serome Atlas

OR2L3

Olfactory receptor 2L3

Also known as: OR2L3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG85
Gene: OR2L3
Ensembl: ENSG00000198128
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NG85|OR2L3
     1  MENYNQTSTD FILLGFFPPS RIGLFLFILI VFIFLMALIG NLSMILLIFL DTHLHTPMYF
    61  LLSQLSLIDL NYISTIVPKM ASDFLSGNKS ISFTGCGIQS FFFSALGGAE ALLLASMAYD
   121  RYIAICFPLH YPIRMSKRMC VLMITGSWII GSINACAHTV YVLHIPYCQS RAINHFFCDV
   181  PAMVTLACMD TWVYEGTVFL STTIFLVFPF IAISCSYGRV LLAVYHMKSA EGRKKAYLTC
   241  STHLTVVTFY YAPFVYTYLR PRSLRSPTED KVLAVFYTTL TPMLNPIIYS LRNKEVMGAL
   301  TRVSQRICSG KM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2L3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

prostate: 0.8 nTPM
bone marrow: 0.7 nTPM
appendix: 0.2 nTPM
retina: 0.2 nTPM
spinal cord: 0.2 nTPM
breast: 0.1 nTPM

Single-cell type

retinal ganglion cells: 27 nCPM
oligodendrocytes: 16 nCPM
hematopoietic stem cells: 16 nCPM
other brain neurons: 13 nCPM
brain inhibitory neurons: 12 nCPM
brain excitatory neurons: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 5.7 nTPM
cerebral cortex: 5.1 nTPM
pons: 4.9 nTPM
hypothalamus: 4.4 nTPM
medulla oblongata: 4.4 nTPM
basal ganglia: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.27
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2L3 as an antibody target. Whether an autoantibody or antibody against OR2L3 could matter depends on whether native OR2L3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2L3 is annotated at the cell surface, where native OR2L3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2L3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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