Seroatlas · Human Serome Atlas

OR2L2

Olfactory receptor 2L2

Also known as: HSHTPCRH07, HTPCRH07, OR2L12, OR2L2_HUMAN, OR2L4P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NH16
Gene: OR2L2
Ensembl: ENSG00000203663
Chromosome: 1
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>Q8NH16|OR2L2
     1  MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL DIHLHTPMYF
    61  LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS FFFLTLAVAE GLLLTSMAYD
   121  RYVAICFPLH YPIRISKRVC VMMITGSWMI SSINSCAHTV YALCIPYCKS RAINHFFCDV
   181  PAMLTLACTD TWVYESTVFL SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC
   241  STHLTVVSFY YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL
   301  TQVIQKIFSV KM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

retina: 1.5 nTPM
spinal cord: 1.2 nTPM
testis: 1 nTPM
bone marrow: 0.8 nTPM
hippocampal formation: 0.4 nTPM
liver: 0.4 nTPM

Single-cell type

oligodendrocytes: 11 nCPM
retinal ganglion cells: 7.7 nCPM
late spermatids: 7.4 nCPM
brain inhibitory neurons: 7.3 nCPM
hematopoietic stem cells: 7.3 nCPM
brain excitatory neurons: 7.2 nCPM

Immune cell

basophil: 0.5 nTPM
neutrophil: 0.4 nTPM
naive B-cell: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM

Brain region

white matter: 18 nTPM
cerebral cortex: 17 nTPM
cerebellum: 15 nTPM
pons: 14 nTPM
thalamus: 13 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.45
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2L2 as an antibody target. Whether an autoantibody or antibody against OR2L2 could matter depends on whether native OR2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2L2 is annotated at the cell surface, where native OR2L2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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