Seroatlas · Human Serome Atlas

OR2K2

Olfactory receptor 2K2

Also known as: HSHTPCRH06, HTPCRH06, OR2AR1P, OR2K2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGT1
Gene: OR2K2
Ensembl: ENSG00000171133
Chromosome: 9
Canonical length: 316 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q8NGT1|OR2K2
     1  MQGENFTIWS IFFLEGFSQY PGLEVVLFVF SLVMYLTTLL GNSTLILITI LDSRLKTPMY
    61  LFLGNLSFMD ICYTSASVPT LLVNLLSSQK TIIFSGCAVQ MYLSLAMGST ECVLLAVMAY
   121  DRYVAICNPL RYSIIMNRCV CARMATVSWV TGCLTALLET SFALQIPLCG NLIDHFTCEI
   181  LAVLKLACTS SLLMNTIMLV VSILLLPIPM LLVCISYIFI LSTILRITSA EGRNKAFSTC
   241  GAHLTVVILY YGAALSMYLK PSSSNAQKID KIISLLYGVL TPMLNPIIYS LRNKEVKDAM
   301  KKLLGKITLH QTHEHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2K2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 0.8 nTPM
midbrain: 0.5 nTPM
skeletal muscle: 0.4 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM
retina: 0.2 nTPM

Single-cell type

late primary spermatocytes: 0.4 nCPM
late spermatids: 0.4 nCPM
cdc: 0.2 nCPM
myonuclei: 0.2 nCPM
oligodendrocytes: 0.2 nCPM
cardiomyocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 0.9 nTPM
basal ganglia: 0.6 nTPM
pons: 0.6 nTPM
medulla oblongata: 0.5 nTPM
thalamus: 0.5 nTPM
midbrain: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: -0.03
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2K2 as an antibody target. Whether an autoantibody or antibody against OR2K2 could matter depends on whether native OR2K2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2K2 is annotated at the cell surface, where native OR2K2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2K2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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