Seroatlas · Human Serome Atlas

OR2J3

Olfactory receptor 2J3

Also known as: OR2J3_HUMAN, OR6-6

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O76001
Gene: OR2J3
Ensembl: ENSG00000204701
Chromosome: 6
Canonical length: 311 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>O76001|OR2J3
     1  MNDDGKVNAS SEGYFILVGF SNWPHLEVVI FVVVLIFYLM TLIGNLFIII LSYLDSHLHT
    61  PMYFFLSNLS FLDLCYTTSS IPQLLVNLWG PEKTISYAGC MIQLYFVLAL GTTECVLLVV
   121  MSYDRYAAVC RPLHYTVLMH PRFCHLLAVA SWVSGFTNSA LHSSFTFWVP LCGHRQVDHF
   181  FCEVPALLRL SCVDTHVNEL TLMITSSIFV LIPLILILTS YGAIVRAVLR MQSTTGLQKV
   241  FGTCGAHLMA VSLFFIPAMC IYLQPPSGNS QDQGKFIALF YTVVTPSLNP LIYTLRNKVV
   301  RGAVKRLMGW E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2J3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late primary spermatocytes: 5.9 nCPM
early spermatids: 4.1 nCPM
late spermatids: 2.9 nCPM
brain inhibitory neurons: 0.2 nCPM
early primary spermatocytes: 0.2 nCPM
undifferentiated spermatogonia: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 2.4 nTPM
midbrain: 2.3 nTPM
spinal cord: 1.6 nTPM
white matter: 1.3 nTPM
pons: 1.2 nTPM
hippocampal formation: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0.01
gnomAD missense Z: 0.2
DepMap mean gene effect: -0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2J3 as an antibody target. Whether an autoantibody or antibody against OR2J3 could matter depends on whether native OR2J3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2J3 is annotated at the cell surface, where native OR2J3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2J3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...