Seroatlas · Human Serome Atlas

OR2I1

Putative olfactory receptor 2I1

Also known as: OR2I1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGU4
Gene: OR2I1
Canonical length: 315 aa

OverviewNCBI Gene

No narrative summary is available for OR2I1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>Q8NGU4|OR2I1
     1  MKANYSAEER FLLLGFSDWP SLQPVLFALV LLCYLLTLTG NSALVLLAVR DPRLHTPMYY
    61  FLCHLALVDA GFTTSVVPPL LANLRGPALW LPRSHCTAQL CASLALGSAE CVLLAVMALD
   121  RAAAVCRPLR YAGLVSPRLC RTLASASWLS GLTNSVAQTA LLAERPLCAP RLLDHFICEL
   181  PALLKLACGG DGDTTENQMF AARVVILLLP FAVILASYGA VARAVCCMRF SGGRRRAVGT
   241  CGSHLTAVCL FYGSAIYTYL QPAQRYNQAR GKFVSLFYTV VTPALNPLIY TLRNKKVKGA
   301  ARRLLRSLGR GQAGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2I1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2I1 as an antibody target. Whether an autoantibody or antibody against OR2I1 could matter depends on whether native OR2I1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2I1 is annotated at the cell surface, where native OR2I1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2I1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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