Seroatlas · Human Serome Atlas

OR2H1

Olfactory receptor 2H1

Also known as: OR2H1_HUMAN, OR2H6, OR2H8, OR6-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZK4
Gene: OR2H1
Ensembl: ENSG00000204688
Chromosome: 6
Canonical length: 316 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q9GZK4|OR2H1
     1  MVNQSSPMGF LLLGFSEHPA LERTLFVVVF TSYLLTLVGN TLIILLSVLY PRLHSPMYFF
    61  LSDLSFLDLC FTTSCVPQML VNLWGPKKTI SFLGCSVQLF IFLSLGTTEC ILLTVMAFDR
   121  YVAVCQPLHY ATIIHPRLCW QLASVAWVMS LVQSIVQTPS TLHLPFCPHQ QIDDFLCEVP
   181  SLIRLSCGDT SYNEIQLAVS SVIFVVVPLS LILASYGATA QAVLRINSAT AWRKAFGTCS
   241  SHLTVVTLFY SSVIAVYLQP KNPYAQGRGK FFGLFYAVGT PSLNPLVYTL RNKEIKRALR
   301  RLLGKERDSR ESWRAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2H1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 8.9 nCPM
late primary spermatocytes: 5.3 nCPM
ependymal cells: 5.1 nCPM
late spermatids: 3.6 nCPM
sertoli cells: 0.3 nCPM
brain excitatory neurons: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.74
gnomAD pLI: 0.53
gnomAD missense Z: -0.46
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2H1 as an antibody target. Whether an autoantibody or antibody against OR2H1 could matter depends on whether native OR2H1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2H1 is annotated at the cell surface, where native OR2H1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2H1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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