Seroatlas · Human Serome Atlas

OR2F1

Olfactory receptor 2F1

Also known as: OLF3, OR14-60, OR2F1_HUMAN, OR2F3, OR2F3P, OR2F4, OR2F5, OR7-139, OR7-140

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13607
Gene: OR2F1
Ensembl: ENSG00000213215
Chromosome: 7
Canonical length: 317 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q13607|OR2F1
     1  MGTDNQTWVS EFILLGLSSD WDTRVSLFVL FLVMYVVTVL GNCLIVLLIR LDSRLHTPMY
    61  FFLTNLSLVD VSYATSVVPQ LLAHFLAEHK AIPFQSCAAQ LFFSLALGGI EFVLLAVMAY
   121  DRYVAVCDAL RYSAIMHGGL CARLAITSWV SGFISSPVQT AITFQLPMCR NKFIDHISCE
   181  LLAVVRLACV DTSSNEVTIM VSSIVLLMTP FCLVLLSYIQ IISTILKIQS REGRKKAFHT
   241  CASHLTVVAL CYGVAIFTYI QPHSSPSVLQ EKLFSVFYAI LTPMLNPMIY SLRNKEVKGA
   301  WQKLLWKFSG LTSKLAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2F1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

syncytiotrophoblasts: 5.9 nCPM
cytotrophoblasts: 3.5 nCPM
late spermatids: 2.1 nCPM
late primary spermatocytes: 2 nCPM
early spermatids: 1.9 nCPM
loop of henle epithelial cells: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: -0.28

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2F1 as an antibody target. Whether an autoantibody or antibody against OR2F1 could matter depends on whether native OR2F1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2F1 is annotated at the cell surface, where native OR2F1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2F1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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