Seroatlas · Human Serome Atlas

OR2C1

Olfactory receptor 2C1

Also known as: OLFmf3, OR2C1_HUMAN, OR2C2P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95371
Gene: OR2C1
Ensembl: ENSG00000168158
Chromosome: 16
Canonical length: 312 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>O95371|OR2C1
     1  MDGVNDSSLQ GFVLMGISDH PQLEMIFFIA ILFSYLLTLL GNSTIILLSR LEARLHTPMY
    61  FFLSNLSSLD LAFATSSVPQ MLINLWGPGK TISYGGCITQ LYVFLWLGAT ECILLVVMAF
   121  DRYVAVCRPL RYTAIMNPQL CWLLAVIACL GGLGNSVIQS TFTLQLPLCG HRRVEGFLCE
   181  VPAMIKLACG DTSLNQAVLN GVCTFFTAVP LSIIVISYCL IAQAVLKIRS AEGRRKAFNT
   241  CLSHLLVVFL FYGSASYGYL LPAKNSKQDQ GKFISLFYSL VTPMVNPLIY TLRNMEVKGA
   301  LRRLLGKGRE VG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2C1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 0.6 nTPM
parathyroid gland: 0.3 nTPM
spinal cord: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
breast: 0.1 nTPM

Single-cell type

astrocytes: 0.2 nCPM
endometrial ciliated cells: 0.2 nCPM
bergmann glia: 0.1 nCPM
fallopian tube ciliated cells: 0.1 nCPM
gonadotrophs: 0.1 nCPM
hofbauer cells: 0.1 nCPM

Immune cell

naive CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

white matter: 1.8 nTPM
amygdala: 1.4 nTPM
cerebral cortex: 1.4 nTPM
medulla oblongata: 1.4 nTPM
basal ganglia: 1.2 nTPM
hippocampal formation: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: -0.53
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2C1 as an antibody target. Whether an autoantibody or antibody against OR2C1 could matter depends on whether native OR2C1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2C1 is annotated at the cell surface, where native OR2C1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2C1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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