Seroatlas · Human Serome Atlas

OR2B8

Olfactory receptor 2B8

Also known as: OR2B8_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59922
Gene: OR2B8
Canonical length: 312 aa

OverviewNCBI Gene

No narrative summary is available for OR2B8 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

312 residues, UniProt reviewed canonical sequence.

>P59922|OR2B8
     1  MDQKNGSSFT GFILLGFSDR PQLELVLFVV LLIFYIFTLL GNKTIIVLSH LDPHLHTPMY
    61  FFFSNLSFLD LCYTTGIVPQ LLVNLRGADK SISYGGCVVQ LYISLGLGST ECVLLGVMVF
   121  DRYAAVCRPL HYTVVMHPCL YVLMASTSWV IGFANSLLQT VLILLLTLCG RNKLEHFLCE
   181  VPPLLKLACV DTTMNESELF FVSVIILLVP VALIIFSYSQ IVRAVMRIKL ATGQRKVFGT
   241  CGSHLTVVSL FYGTAIYAYL QPGNNYSQDQ GKFISLFYTI ITPMINPLIY TLRNKDVKGA
   301  LKKVLWKNYD SR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2B8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2B8 as an antibody target. Whether an autoantibody or antibody against OR2B8 could matter depends on whether native OR2B8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2B8 is annotated at the cell surface, where native OR2B8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2B8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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