Seroatlas · Human Serome Atlas

OR2AP1

Olfactory receptor 2AP1

Also known as: O2AP1_HUMAN, OR2AP1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGE2
Gene: OR2AP1
Ensembl: ENSG00000179615
Chromosome: 12
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q8NGE2|OR2AP1
     1  MKNKTVLTEF ILLGLTDVPE LQVAVFTFLF LAYLLSILGN LTILILTLLD SHLQTPMYFF
    61  LRNFSFLEIS FTNIFIPRVL ISITTGNKSI SFAGCFTQYF FAMFLGATEF YLLAAMSYDR
   121  YVAICKPLHY TTIMSSRICI QLIFCSWLGG LMAIIPTITL MSQQDFCASN RLNHYFCDYE
   181  PLLELSCSDT SLIEKVVFLV ASVTLVVTLV LVILSYAFII KTILKLPSAQ QRTKAFSTCS
   241  SHMIVISLSY GSCMFMYINP SAKEGDTFNK GVALLITSVA PLLNPFIYTL RNQQVKQPFK
   301  DMVKKLLNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2AP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

retina: 0.4 nTPM
bone marrow: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

cardiomyocytes: 1.5 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.3 nTPM
cerebral cortex: 2 nTPM
cerebellum: 1.8 nTPM
hippocampal formation: 1.6 nTPM
pons: 1.6 nTPM
amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -1.16
DepMap mean gene effect: -0.12
DepMap dependency class: selective

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2AP1 as an antibody target. Whether an autoantibody or antibody against OR2AP1 could matter depends on whether native OR2AP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2AP1 is annotated at the cell surface, where native OR2AP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2AP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...