Seroatlas · Human Serome Atlas

OR2AK2

Olfactory receptor 2AK2

Also known as: O2AK2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG84
Gene: OR2AK2
Canonical length: 335 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR2AK2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q8NG84|OR2AK2
     1  MNISDVISFD ILVSAMKTGN QSFGTDFLLV GLFQYGWINS LLFVVIATLF TVALTGNIML
    61  IHLIRLNTRL HTPMYFLLSQ LSIVDLMYIS TTVPKMAVSF LSQSKTIRFL GCEIQTYVFL
   121  ALGGTEALLL GFMSYDRYVA ICHPLHYPML MSKKICCLMV ACAWASGSIN AFIHTLYVFQ
   181  LPFCRSRLIN HFFCEVPALL SLVCQDTSQY EYTVLLSGLI ILLLPFLAIL ASYARVLIVV
   241  FQMSSGKGQA KAVSTCSSHL IVASLFYATT LFTYTRPHSL RSPSRDKAVA VFYTIVTPLL
   301  NPFIYSLRNK EVTGAVRRLL GYWICCRKYD FRSLY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2AK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.2 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

late spermatids: 2 nCPM
oligodendrocytes: 1.1 nCPM
breast myoepithelial cells: 0.9 nCPM
early spermatids: 0.8 nCPM
late primary spermatocytes: 0.8 nCPM
brain excitatory neurons: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 5 nTPM
cerebral cortex: 4.6 nTPM
hypothalamus: 4.3 nTPM
pons: 4 nTPM
medulla oblongata: 3.7 nTPM
thalamus: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2AK2 as an antibody target. Whether an autoantibody or antibody against OR2AK2 could matter depends on whether native OR2AK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2AK2 is annotated at the cell surface, where native OR2AK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2AK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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