OR2AJ1
Olfactory receptor 2AJ1
Also known as: O2AJ1_HUMAN, OR2AJ1P, OR2AJ1Q
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NGZ0
- Gene
- OR2AJ1
- Ensembl
- ENSG00000177275
- Chromosome
- 1
- Canonical length
- 328 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
328 residues, UniProt reviewed canonical sequence.
>Q8NGZ0|OR2AJ1
1 MGHQNHTFSS DFILLGLFSS SPTSVVFFLV LFVIFIMSVT ENTLMILLIR SDSRLHTPMY
61 FLLSHLSLMD ILHVSNIVPK MVTNFLSGSR TISFAGCGFQ VFLSLTLLGG ECLLLAAMSC
121 DRYVAICHPL RYPILMKEYA SALMAGGSWL IGVFNSTVHT AYALQFPFCG SRAIDHFFCE
181 VPAMLKLSCA DTTRYERGVC VSAVIFLLIP FSLISASYGQ IILTVLQMKS SEARKKSFST
241 CSFHMIVVTM YYGPFIFTYM RPKSYHTPGQ DKFLAIFYTI LTPTLNPFIY SFRNKDVLAV
301 MKNMLKSNFL HKKMNRKIPE CVFCLFLCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against OR2AJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.28
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- spleen: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- megakaryocytes: 6.2 nCPM
- cone photoreceptor cells: 4.1 nCPM
- hematopoietic stem cells: 2.4 nCPM
- megakaryocyte-erythroid progenitors: 2.4 nCPM
- parietal cells: 1.8 nCPM
- brain inhibitory neurons: 1.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- hypothalamus: 0.7 nTPM
- cerebral cortex: 0.4 nTPM
- pons: 0.4 nTPM
- medulla oblongata: 0.3 nTPM
- midbrain: 0.3 nTPM
- spinal cord: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.86
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 1.29
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads OR2AJ1 as an antibody target. Whether an autoantibody or antibody against OR2AJ1 could matter depends on whether native OR2AJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
OR2AJ1 is annotated at the cell surface, where native OR2AJ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label OR2AJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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