Seroatlas · Human Serome Atlas

OR2A7

Olfactory receptor 2A7

Also known as: HSDJ0798C17, OR2A7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96R45
Gene: OR2A7
Ensembl: ENSG00000243896
Chromosome: 7
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q96R45|OR2A7
     1  MGDNITSITE FLLLGFPVGP RIQMLLFGLF SLFYVFTLLG NGTILGLISL DSRLHAPMYF
    61  FLSHLAVVDI AYACNTVPRM LVNLLHPAKP ISFAGRMMQT FLFSTFAVTE CLLLVVMSYD
   121  LYVAICHPLR YLAIMTWRVC ITLAVTSWTT GVLLSLIHLV LLLPLPFCRP QKIYHFFCEI
   181  LAVLKLACAD THINENMVLA GAISGLVGPL STIVVSYMCI LCAILQIQSR EVQRKAFCTC
   241  FSHLCVIGLF YGTAIIMYVG PRYGNPKEQK KYLLLFHSLF NPMLNPLICS LRNSEVKNTL
   301  KRVLGVERAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

skin: 12 nTPM
thyroid gland: 11 nTPM
duodenum: 9.9 nTPM
kidney: 7.3 nTPM
small intestine: 7.1 nTPM
pancreas: 6.2 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 12 nTPM
naive B-cell: 2 nTPM
NK-cell: 1.5 nTPM
memory CD4 T-cell: 1 nTPM
gdT-cell: 0.7 nTPM
T-reg: 0.7 nTPM

Brain region

choroid plexus: 5.6 nTPM
midbrain: 3.3 nTPM
medulla oblongata: 2.7 nTPM
thalamus: 2.7 nTPM
pons: 2.6 nTPM
basal ganglia: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.37
gnomAD missense Z: 1.01

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2A7 as an antibody target. Whether an autoantibody or antibody against OR2A7 could matter depends on whether native OR2A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2A7 is annotated at the cell surface, where native OR2A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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