Seroatlas · Human Serome Atlas

OR2A4

Olfactory receptor 2A4

Also known as: OR2A10, OR2A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95047
Gene: OR2A4
Ensembl: ENSG00000180658
Chromosome: 6
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>O95047|OR2A4
     1  MGDNITSIRE FLLLGFPVGP RIQMLLFGLF SLFYVFTLLG NGTILGLISL DSRLHAPMYF
    61  FLSHLAVVDI AYACNTVPRM LVNLLHPAKP ISFAGRMMQT FLFSTFAVTE CLLLVVMSYD
   121  LYVAICHPLR YLAIMTWRVC ITLAVTSWTT GVLLSLIHLV LLLPLPFCRP QKIYHFFCEI
   181  LAVLKLACAD THINENMVLA GAISGLVGPL STIVVSYMCI LCAILQIQSR EVQRKAFRTC
   241  FSHLCVIGLV YGTAIIMYVG PRYGNPKEQK KYLLLFHSLF NPMLNPLICS LRNSEVKNTL
   301  KRVLGVERAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

prostate: 0.3 nTPM
liver: 0.2 nTPM
adrenal gland: 0.1 nTPM
cervix: 0.1 nTPM
choroid plexus: 0.1 nTPM
duodenum: 0.1 nTPM

Single-cell type

mast cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 12 nTPM
NK-cell: 2.7 nTPM
intermediate monocyte: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 0.4 nTPM
cerebral cortex: 0.2 nTPM
pons: 0.2 nTPM
basal ganglia: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0.12
gnomAD missense Z: 0.8

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2A4 as an antibody target. Whether an autoantibody or antibody against OR2A4 could matter depends on whether native OR2A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2A4 is annotated at the cell surface, where native OR2A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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