Seroatlas · Human Serome Atlas

OR2A1

Olfactory receptor 2A1/2A42

Also known as: OR2A1_HUMAN, OR2A42

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGT9
Gene: OR2A1
Ensembl: ENSG00000221970
Chromosome: 7
Canonical length: 310 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q8NGT9|OR2A1
     1  MGENQTMVTE FLLLGFLLGP RIQMLLFGLF SLFYIFTLLG NGAILGLISL DSRLHTPMYF
    61  FLSHLAVVDI AYTRNTVPQM LANLLHPAKP ISFAGCMTQT FLCLSFGHSE CLLLVLMSYD
   121  RYVAICHPLR YSVIMTWRVC ITLAVTSWTC GSLLALAHVV LILRLPFSGP HEINHFFCEI
   181  LSVLRLACAD TWLNQVVIFA ACVFFLVGPP SLVLVSYSHI LAAILRIQSG EGRRKAFSTC
   241  SSHLCVVGLF FGSAIIMYMA PKSRHPEEQQ KVFFLFYSFF NPTLNPLIYS LRNGEVKGAL
   301  RRALGKESHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 1.3 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 1.3 nTPM
skin: 0.9 nTPM
bone marrow: 0.5 nTPM
duodenum: 0.5 nTPM
ovary: 0.5 nTPM
kidney: 0.4 nTPM

Single-cell type

renal collecting duct principal cells: 1 nCPM
loop of henle epithelial cells: 0.8 nCPM
late spermatids: 0.3 nCPM
fibroblasts: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM
proximal tubule cells: 0.2 nCPM

Immune cell

basophil: 0.2 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
NK-cell: 0.1 nTPM
T-reg: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 3.2 nTPM
thalamus: 1.7 nTPM
amygdala: 1.6 nTPM
midbrain: 1.6 nTPM
basal ganglia: 1.5 nTPM
pons: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: 1.05

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of smell

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR2A1 as an antibody target. Whether an autoantibody or antibody against OR2A1 could matter depends on whether native OR2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR2A1 is annotated at the cell surface, where native OR2A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR2A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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