Seroatlas · Human Serome Atlas

OR1S2

Olfactory receptor 1S2

Also known as: OR1S2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGQ3
Gene: OR1S2
Canonical length: 325 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for OR1S2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q8NGQ3|OR1S2
     1  MKTLCSFLQI SRNMHQENQT TITEFILLGL SNQAEHQNLL FVLFLSMYVV TVVGNGLIIV
    61  AISLDIYLHT PMYLFLAYLS FADISSISNS VPKMLVNIQT NSQSISYESC ITQMYFSIVF
   121  VVTDNLLLGT MAFDHFVAIC HPLNYTTFMR ARFGTLLTVI SWFLSNIIAL THTLLLIQLL
   181  FCDHNTLPHF FCDLAPLLKL SCSDTMINEL VLFIVGLSVI IFPFVLIFFS YVCIIRAVLG
   241  VSSTQGKWKA FSTCGSHLTI ALLFYGTTVG VYFFPSSTHP EDTDKIGAVL FTVVTPMMNP
   301  FIYSLRNKDM KGALRKLINR KISSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1S2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -1.61

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1S2 as an antibody target. Whether an autoantibody or antibody against OR1S2 could matter depends on whether native OR1S2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1S2 is annotated at the cell surface, where native OR1S2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1S2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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