Seroatlas · Human Serome Atlas

OR1L8

Olfactory receptor 1L8

Also known as: OR1L8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGR8
Gene: OR1L8
Ensembl: ENSG00000171496
Chromosome: 9
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q8NGR8|OR1L8
     1  MERINHTSSV SEFILLGLSS RPEDQKTLFV LFLIVYLVTI TGNLLIILAI RFNPHLQTPM
    61  YFFLSFLSLT DICFTTSVVP KMLMNFLSEK KTISYAGCLT QMYFLYALGN SDSCLLAVMA
   121  FDRYVAVCDP FHYVTTMSHH HCVLLVAFSC SFPHLHSLLH TLLLNRLTFC DSNVIHHFLC
   181  DLSPVLKLSC SSIFVNEIVQ MTEAPIVLVT RFLCIAFSYI RILTTVLKIP STSGKRKAFS
   241  TCGFYLTVVT LFYGSIFCVY LQPPSTYAVK DHVATIVYTV LSSMLNPFIY SLRNKDLKQG
   301  LRKLMSKRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1L8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

spleen: 0.6 nTPM
testis: 0.3 nTPM
adipose tissue: 0.2 nTPM
endometrium: 0.2 nTPM
retina: 0.2 nTPM
salivary gland: 0.2 nTPM

Single-cell type

mast cells: 6.6 nCPM
rod photoreceptor cells: 6.3 nCPM
hematopoietic stem cells: 3.9 nCPM
late spermatids: 3.2 nCPM
platelets: 2.8 nCPM
respiratory ionocytes: 2.5 nCPM

Immune cell

basophil: 0.3 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
hippocampal formation: 1.3 nTPM
amygdala: 1 nTPM
basal ganglia: 1 nTPM
white matter: 1 nTPM
hypothalamus: 0.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0.09
gnomAD missense Z: 0.34
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1L8 as an antibody target. Whether an autoantibody or antibody against OR1L8 could matter depends on whether native OR1L8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1L8 is annotated at the cell surface, where native OR1L8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1L8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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