Seroatlas · Human Serome Atlas

OR1L6

Olfactory receptor 1L6

Also known as: OR1L6_HUMAN, OR1L7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGR2
Gene: OR1L6
Ensembl: ENSG00000171459
Chromosome: 9
Canonical length: 347 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q8NGR2|OR1L6
     1  MSYFYRLKLM KEAVLVKLPF TSLPLLLQTL SRKSRDMEIK NYSSSTSGFI LLGLSSNPQL
    61  QKPLFAIFLI MYLLAAVGNV LIIPAIYSDP RLHTPMYFFL SNLSFMDICF TTVIVPKMLV
   121  NFLSETKVIS YVGCLAQMYF FMAFGNTDSY LLASMAIDRL VAICNPLHYD VVMKPRHCLL
   181  MLLGSCSISH LHSLFRVLLM SRLSFCASHI IKHFFCDTQP VLKLSCSDTS SSQMVVMTET
   241  LAVIVTPFLC IIFSYLRIMV TVLRIPSAAG KWKAFSTCGS HLTAVALFYG SIIYVYFRPL
   301  SMYSVVRDRV ATVMYTVVTP MLNPFIYSLR NKDMKRGLKK LQDRIYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1L6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

epicardial cells: 4.5 nCPM
hematopoietic stem cells: 1.9 nCPM
retinal amacrine cells: 1.4 nCPM
fibro-adipogenic progenitors: 1 nCPM
adipocytes: 0.7 nCPM
macrophages: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.1 nTPM
thalamus: 1.1 nTPM
medulla oblongata: 0.9 nTPM
pons: 0.9 nTPM
basal ganglia: 0.8 nTPM
white matter: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.53
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1L6 as an antibody target. Whether an autoantibody or antibody against OR1L6 could matter depends on whether native OR1L6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1L6 is annotated at the cell surface, where native OR1L6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1L6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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