Seroatlas · Human Serome Atlas

OR1J1

Olfactory receptor 1J1

Also known as: hg32, OR1J1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NGS3
Gene: OR1J1
Ensembl: ENSG00000136834
Chromosome: 9
Canonical length: 322 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q8NGS3|OR1J1
     1  MSPENQSSVS EFLLLGLPIR PEQQAVFFAL FLGMYLTTVL GNLLIMLLIQ LDSHLHTPMY
    61  FFLSHLALTD ISFSSVTVPK MLMNMQTQHL AVFYKGCISQ TYFFIFFADL DSFLITSMAY
   121  DRYVAICHPL HYATIMTQSQ CVMLVAGSWV IACACALLHT LLLAQLSFCA DHIIPHYFCD
   181  LGALLKLSCS DTSLNQLAIF TAALTAIMLP FLCILVSYGH IGVTILQIPS TKGICKALST
   241  CGSHLSVVTI YYRTIIGLYF LPPSSNTNDK NIIASVIYTA VTPMLNPFIY SLRNKDIKGA
   301  LRKLLSRSGA VAHACNLNTL GG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OR1J1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.1 nTPM
choroid plexus: 0.1 nTPM
retina: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

differentiating spermatogonia: 0.2 nCPM
endometrial glandular cells: 0.2 nCPM
endometrial luminal cells: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM
rod photoreceptor cells: 0.2 nCPM
undifferentiated spermatogonia: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
hippocampal formation: 1.1 nTPM
hypothalamus: 0.9 nTPM
white matter: 0.8 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.83
gnomAD pLI: 0
gnomAD missense Z: -0.55
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OR1J1 as an antibody target. Whether an autoantibody or antibody against OR1J1 could matter depends on whether native OR1J1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OR1J1 is annotated at the cell surface, where native OR1J1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label OR1J1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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